OBSERVATIONS ON THE CONTINUED USE OF MALE SEX HORMONE OVER LONG PERIODS OF TIME

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Abstract
The 4 cases detailed are: (1) A [male], age 28 yrs., with a pluriglandular dyscrasia, the predominant picture being hypogonadism, atypical eunuchoidism and gynecomastia; treated with 50 to 60 mg. oreton weekly; the total amt. of testosterone propionate used thus far[long dash]2800 mg.; (2) A [male], age 21 yrs., diagnosed as post-castration, typical eunuchism, treated with 50 to 60 mg. oreton weekly; the total amt. of testosterone propionate used thus far being 3250 mg.; (3) A [male], age 21 yrs., diagnosed as a modified Lorain-Levi hypopituitarism, treated with 50 to 60 mg. oreton weekly, the total amt. of testosterone propionate to date being more than 3400 mg.; (4) A [male], 28 yrs. of age, typical Lorain-Levi infantilism, given 50 to 60 mg. oreton weekly, having used 3500 mg. testosterone propionate to date. Some of the effects are changes in the physical characteristics, changes in configuration, growth of axillary, supra-pubic and body hair, slight growth of facial hair, change in voice, growth of Pomum Adami, growth of genitalia, growth of scrotum, appearance and increase of ejaculations, appearance and increase of libido and erection, desirable and agreeable psychic and mental changes, gain, in wt. Some of the points made include the teaching of self-adm. (each patient regarding himself deficient in testosterone, as the diabetic is deficient in insulin); it is replacement therapy; omission of treatment for 2 or more wks. brings regressions; the avg. maintenance dose is 50 to 60 mg.; continued therapy has brought no untoward symptoms; combined therapy may be necessary for optimum benefits; and the uncontrolled sale of testosterone propionate should be replaced by a controlled sale on prescription (as with narcotics).

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