Thyroid Stimulating Hormone Downregulates Vascular Endothelial Growth Factor Expression in FRTL-5 Cells
- 1 June 2001
- journal article
- research article
- Published by Mary Ann Liebert Inc in Thyroid®
- Vol. 11 (6) , 539-543
- https://doi.org/10.1089/105072501750302831
Abstract
We studied the regulation of the expression of vascular endothelial growth factor (VEGF) by TSH in monolayer cultures of rat thyroid FRTL-5 cell lines. The VEGF mRNA synthesis was significantly inhibited by TSH as well as dibutyryl cyclic adenosine monophosphate (cAMP) in a dose-dependent manner in FRTL-5 cells. This observation is contrary to previously published results using the thyroid follicular culture system. Our results suggest that the direct effect of TSH/cAMP is to inhibit the VEGF synthesis in monolayer cells.Keywords
This publication has 33 references indexed in Scilit:
- Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cellsPublished by Elsevier ,2004
- Angiogenesis: a Dynamic Balance of Stimulators and InhibitorsThrombosis and Haemostasis, 1997
- Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.Journal of Clinical Investigation, 1993
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisNature, 1992
- Regulators of AngiogenesisAnnual Review of Physiology, 1991
- Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.Proceedings of the National Academy of Sciences, 1990
- Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGFScience, 1989
- Vascular Endothelial Growth Factor Is a Secreted Angiogenic MitogenScience, 1989
- Angiogenic FactorsScience, 1987
- Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites FluidScience, 1983