Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa

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Abstract
The low molecular weight form of insulin-like growth factor binding prtein (35 kD IGFBP), determined in serum by radioimmunoassay during non-fasting conditions, was high at birth and declined with increasing age during childhood and adolescence (N = 149). Inverse correlation was found between chronological age and 35 kD IGFBP values (r = -0.61, P < 0.001) during childhood and adolescence, but no age dependency was found in adult subjects aged 20-66 years (N = 73). The mean and 95% confienced limits of immunoreative 35 kD IGFBP were 34 .mu.g/l in whom the blood samples were drawn after a one-night fast. The mean level of the 35 kD IGFBP in patients with acromegaly (19 .mu.g/l, N = 23) was decreased by 50% in comparion with healthy adults, whereas a 2-fold elevation of the mean levels was found in both anorexia nervosa patients (70 .mu.g/l, N = 13) and adult patients with GH deficiency (69 .mu.g/l, N = 22). In patients with anorexia nervosa, the 35 kD IGFBP levels were inversely related to the body mass index (r = -0.65, P < 0.02).

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