Thrombus Formation in the Arterial and Venous Circulation in Thrombocytopenic Dogs

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Abstract
Arterial and venous thrombus formation and composition were studied in dogs made thrombocytopenic by injection of antiplatelet serum. At platelet counts below 10,000/mm3 almost no thrombi were formed in arteries, whereas thrombus formation still took place in eins. The fibrin content of the thrombi, as estimated by 125I-labelled fibrinogen, was markedly higher in thrombi formed at platelet counts below 30,000/ mm3, as compared to thrombi formed at higher platelet counts. The present results suggest that a primary nidus of adhering and aggregating platelets is necessary for thrombus formation in arteries. In veins thrombi can develop despite a marked thrombocytopenia.

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