THP-ADM in the treatment of acute promyelocytic leukemia.

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Abstract
Three patients, diagnosed as acute promyelocytic leukemia and disseminated intravascular coagulation (DIC), were treated with THP-ADM [4-o-tetrahydropyranyl adriamycin] in combination with heparin and intensive platelet transfusion. Of the 3 patients 2 achieved complete remission. The remaining patient also responded favorably to the therapy and achieved marrow aplasia, and significant improvement of coagulopathy was observed after chemotherapy. However, he suddenly died of intractable congestive cardiac disturbance 10 days after the completion of THP-ADM induction therapy. The mechanism of this unique delayed anthracycline-associated cardiotoxicity was discussed.