Diastereo- and enantio-selective synthesis of 6-heterosubstituted-3,5-dihydroxyesters: novel precursors of mevinolin analogues
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 5,p. 609-610
- https://doi.org/10.1039/cc9960000609
Abstract
The diastereoselective addition of 1,3-bis(trimethylsilyloxy)-1-methoxybutadiene 2 to readily available α-heterosubstituted aldehydes (S)-1 affords after syn-diastereoselective reduction HMG-CoA-reductase inhibitor-precursors (S,R,S)-4 and 5 with various substitution patterns and high enantiomeric and diastereoisomeric excesses (ee = 93–>96%; de = 95–>96%) in good yields.Keywords
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