Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation
Top Cited Papers
- 1 April 2007
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 25 (1) , 139-170
- https://doi.org/10.1146/annurev.immunol.25.022106.141606
Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective adoptive cellular immunotherapy for the treatment of a number of cancers. The immunobiology of allogeneic HSCT is unique in transplantation in that it involves potential immune recognition and attack between both donor and host. Much of the immunobiology of allogeneic HSCT has been gleaned from preclinical models and correlation with clinical observations. We review our current understanding of some of the issues that affect the success of this therapy, including host-versus-graft (HVG) reactions, graft-versus-host disease (GVHD), graft-versus-tumor (GVT) activity, and restoration of functional immunity to prevent transplant-related opportunistic infections. We also review new strategies to optimize the GVT and improve overall immune function while reducing GVHD and graft rejection.Keywords
This publication has 226 references indexed in Scilit:
- An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissuesThe Journal of Experimental Medicine, 2006
- NK cells promote transplant tolerance by killing donor antigen-presenting cellsThe Journal of Experimental Medicine, 2006
- CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsThe Journal of Experimental Medicine, 2006
- Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsThe Journal of Experimental Medicine, 2006
- Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapyThe Journal of Experimental Medicine, 2006
- Increase of CCR7− CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host diseaseLeukemia, 2006
- Lack of correlation between an assay used to determine early marrow allograft rejection and long-term chimerism after murine allogeneic bone marrow transplantation: Effects of marrow doseTransplantation and Cellular Therapy, 2005
- FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigennonidentical unrelated canine model1Transplantation, 2003
- THE ROLE OF HOST T CELL SUBSETS IN BONE MARROW REJECTION DIRECTED TO ISOLATED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I VERSUS CLASS II DIFFERENCES OF bm1 and bm12 MUTANT MICE1,2Transplantation, 1994
- A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host diseaseNature, 1983