PHOTOSENSITIZING PROPERTIES OF BACTERIOCHLOROPHYLLIN a and BACTERIOCHLORIN a, TWO DERIVATIVES OF BACTERIOCHLOROPHYLL a

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Abstract
The photosensitizing properties of two water soluble derivatives of bacteriochlorophylla, bacteriochlorophyllinaand bacteriochlorina(lacking the central Mg‐ion) were investigated and compared to those of hematoporphyrin derivatives. At physiological pH the oxygen consumption rate of histidine, tryptophan, dithiothreitol and guanosine upon illumination was 3 to 4 times higher when bacteriochlorinawas used as photosensitizer than when hematoporphyrin derivatives were used. Especially bacteriochlorinaproved to be an effective sensitizer for the killing of L929 cells. Because bacteriochlorinahas an absorption maximum at 765 nm in phosphate buffered saline (allowing a light penetration in tissue about ten times larger than at 630 nm) and a high molar absorption coefficient (32 000Mcm−1) it has promising possibilities for the application in photodynamic therapy.

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