THE EFFECTS OF THE ADRENOLYTICS ON THE CATECHOLAMINE CONTENT OF VARIOUS TISSUES IN RABBIT

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Abstract
In the intact rabbits the administration of 10 mg/kg of dibenamine increased the tissue catecholamine and the increase was significantly marked in the spleen. The intravenous administration of 5 mg/kg of chlorpromazine produced the increase of the noradrenaline content in the brain stem by about 30% without a significant change in other tissues. On the other hand, the administration of 1 mg/kg of yohimbine decreased the content of the catecholamine in the brain cortex, brain stem, atria, spleen and adrenals uniformly. In the spinal rabbits the catecholamine content in the brain cortex and adrenals was reduced by about 30%, while the nor-epinephrine content in the atria and spleen was slightly increased. The administration of dibenamine decreased the content of norepinephrine in the brain stem. The spinal rabbits showed a marked reduction of the catecholamine content in the spleen in response to the adrenolytics studied. Some reduction of the norepinephrine content in the atria was found in response to dibenamine and chlorpromazine. No significant change of the content of catecholamine in the brain cortex and adrenals of the spinal rabbits was observed by the intravenous administration of the adrenolytics.