Thiazorifamycins. III. Biosynthesis of rifamycins P,Q and verde, novel metabolites from a mutant of Nocardia mediterranea.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (8) , 842-846
- https://doi.org/10.7164/antibiotics.33.842
Abstract
The thiazorifamycins are derived from rifamycin S and cysteine; rifamycins P and Verde are formed by chemical reactions, while rifamycin Q synthesis involves obligatory enzymatic assistance. All antibiotics come from a common 6-member precursor lacking C-1 of cysteine; the thiazin-2-one ring of rifamycin Verde retains both C-2 and C-3 of cysteine, while the thiazole ring of rifamycins P and Q retains only C-2, C-3 becoming exocyclic in the ring-contraction C-3 is present in rifamycin Q but not in P.This publication has 1 reference indexed in Scilit:
- Rifamycin R, a novel metabolite from a mutant of Nocardia mediterranea.The Journal of Antibiotics, 1978