X-CHROMOSOMES ATTACHED BY THEIR LONG ARM - REPLICATION AUTONOMY OF SHORT ARM ADJACENT TO INACTIVE CENTROMERE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 20  (3) , 179-183
Abstract
A 16 yr old girl with Turner''s syndrome had a 45,X/46,X,t(XqXq)?(q27q23) constitution. The 2 X chromosomes are attached by their long arms with loss of chromosome material and have 1 active and 1 inactive centromere. Analysis of replication patterns with autoradiography and BUdr [bromodeoxyuridine] treatment showed that the abnormal X is always the late replicating chromosome. The short arm of the 2nd X, which is adjacent to the inactive centromere, maintains a degree of replication autonomy from the rest of the long arm.

This publication has 0 references indexed in Scilit: