Synthesis of PyrroloisoquinolonesviaOrganolithium Additions toN-Phenethylsuccinimides
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (01) , 41-42
- https://doi.org/10.1055/s-1993-22340
Abstract
In the presence of n-butyl and t-butyllithium, N-phenethylsuccinimides undergo carbophilic addition to the carbonyl group previous to metal-hydrogen or metal-bromine exchange, while preferential aromatic metalation takes place on the iodinated imide. The cyclizations of the resulting organolithiums allow new and convenient entries to 8,9-dialkoxypyrrolo-[2,1-a]-isoquinolin-3(2H)-ones.Keywords
This publication has 0 references indexed in Scilit: