The structure of baumycins A1, A2, B1, B2, C1 and C2.

Publisher Website
Google Scholar
Abstract
The baumycins are antitumor antibiotics. A2 had the same planar structure as A1. A1 and A2 are considered to be stereoisomers. Baumycins B1 and B2 have the same molecular formula, C34H41NO14 and their mild acid hydrolyses gave daunomycin. Baumycins C1 and C2 have the molecular formula C28H29NO11 and C28H31NO11, respectively. Acid hydrolyses gave daunomycinone and dihydrodaunomycinone, respectively. The structures of C1 and C2 are proposed to be N-formyldaunomycin and N-formyldihydrodaunomycin, respectively. The structure of C1 was confirmed by direct comparison with the N-formyl derivative of daunomycin prepared by treatment of daunomycin base with 1 equivalent of formic acid and dicyclohexylcarbodiimide in chloroform (O.degree. C, 10 min).

This publication has 1 reference indexed in Scilit: