Effect of Subcutaneous Injury on Tumor Growth in the Mouse.

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Abstract
When a subcut. inflammation is induced in the mouse through mechanical injury, and when into such a traumatized site a fragment of exptl. sarcoma is deposited, a striking edematous reaction ensues, accompanied by a conspicuous acceleration of tumor growth; these associated phenomena being well defined by the 4th to 6th day after implantation. This effect is construed as a specific interaction between the neo-plastic characteristics of the tumor fragment and the cellular and/or vascular sequences of subcut. inflammation. The effect does not occur when non-malignant tissues are similarly implanted.

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