Effect of Thyrocalcitonin, Administered During Peritoneal Lavage, on Removal of Bone Salts and Their Radioisotopes.

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Abstract
The effect of porcine thyrocalcitonin was studied in the rat using an experimental system which produces a high rate of bone resorption, that of peritoneal lavage with a calcium and phosphate-free rinse. Thyrocalcitonin was administered either as a single injection following the 3rd hour of lavage, or as multiple injections administered at intervals of 2 to 3 hr. The hypocalcemic agent produced a marked suppression in removal rates of Ca, PO4 and their radioisotopes. It was also effective in animals parathyroidectomized 12 hr. prior to lavage, although the recovery in these animals was slower than in those with intact parathyroid glands. In all cases, the removal of radioactive isotopes administered 2 or more weeks prior to use of the animals was suppressed to a greater degree than those recently administered. Mg removal was not affected by administration of thyrocalcitonin. These studies support the conclusion that the primary action of the new hormone is related to its ability to rapidly reduce bone resorption. It is also suggested that while thyrocalcitonin inhibits parathyroid action, the 2 hormones are not solely antagonistic to each other.

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