Ceftazidime as a single agent in the treatment of severe Pseudomonas aeruginosa infections
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 12 (suppl A) , 207-211
- https://doi.org/10.1093/jac/12.suppl_a.207
Abstract
Ceftazidime was administered intravenously in doses of 1 to 6 g/day to 21 patients with serious Pseudomonas aeruginosa infections (12 pulmonary, 6 septicaemias, 3 urinary tract infections). Mean MIC was 1.0 mg/1. Eighteen (86%) of the 21 patients responded satisfactorily (cured or improved). The selection or emergence of resistant organisms during treatment (mostly Candida, Staphylococcus aureus , and enterococci) was noted in 6 patients. Toxicity was minimal (eosinophila and reversible mild liver function abnormalities).Keywords
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