THE INVIVO QUANTITATION AND KINETICS OF MONOCYTE MIGRATION INTO ACUTE INFLAMMATORY TISSUE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 103  (1) , 47-55
Abstract
Mononuclear leukocytes isolated from the blood of rabbits were labeled with 51Cr and returned to the animal i.v. 51Cr-labeled monocytes disappeared from the blood with a half-life of 39.0 .+-. 2.51 h. Numerous acute inflammatory lesions were produced by the intradermal injection of Escherichia coli into the skin of the back of a rabbit. The animal was sacrificed after 1 h and the radioactivity in each lesion was determined. Monocyte accumulation was substantial by the time a lesion was 1 h old. the maximum rate of accumulation occurred at 3-4 h, and monocytes continued to enter the lesions at 25% of the maximal rate for at least 24 h. Monocytes initially migrate into bacterial inflammatory sites simultaneously with neutrophils and histologically become the predominant cell type after 12 h because they continue to migrate into these lesions long after neutrophils have stopped. The kinetics of monocyte migration is related to other aspects of inflammation.

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