Enzyme discrimination between conformational enantiomers as a means of effecting asymmetric syntheses
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 469-470
- https://doi.org/10.1039/c39770000469
Abstract
Enzymes have been used to effect asymmetric syntheses with chiral molecules which are racemic at room temperature since their conformers are enantiomeric; stereospecific horse liver alcohol dehydrogenase-catalysed oxidations in high (80%) yields of cis-1,2-bis-(hydroxymethyl)cyclohexane and its Δ4-analogue to (1S,2R)-cis-2-hydroxymethylcyclohexanecarboxylic acid lactone (optically pure) and the corresponding (1S,6R)-Δ3-lactone (85% optically pure), respectively, have been carried out.Keywords
This publication has 1 reference indexed in Scilit:
- Stereoselective horse liver alcohol dehydrogenase catalyzed oxidoreductions of some bicyclic [2.2.1] and [3.2.1] ketones and alcoholsJournal of the American Chemical Society, 1976