Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing
Top Cited Papers
- 1 November 2008
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 10 (11) , 1869-1882
- https://doi.org/10.1089/ars.2008.2121
Abstract
Diabetic foot disease is a major health problem, which affects 15% of the 200 million patients with diabetes worldwide. Diminished peripheral blood flow and decreased local neovascularization are critical factors that contribute to the delayed or nonhealing wounds in these patients. The correction of impaired local angiogenesis may be a key component in developing therapeutic protocols for treating chronic wounds of the lower extremity and diabetic foot ulcers. Endothelial progenitor cells (EPCs) are the key cellular effectors of postnatal neovascularization and play a central role in wound healing, but their circulating and wound-level numbers are decreased in diabetes, implicating an abnormality in EPC mobilization and homing mechanisms. The deficiency in EPC mobilization is presumably due to impairment of eNOS-NO cascade in bone marrow (BM). Hyperoxia, induced by a clinically relevant hyperbaric oxygen therapy (HBO) protocol, can significantly enhance the mobilization of EPCs from the BM into peripheral blood. However, increased circulating EPCs failed to reach to wound tissues. This is partly a result of downregulated production of SDF-1α in local wound lesions with diabetes. Administration of exogenous SDF-1α into wounds reversed the EPC homing impairment and, with hyperoxia, synergistically enhanced EPC mobilization, homing, neovascularization, and wound healing. Antioxid. Redox Signal. 10, 1869–1882.Keywords
This publication has 145 references indexed in Scilit:
- Getting to the site of inflammation: the leukocyte adhesion cascade updatedNature Reviews Immunology, 2007
- Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord bloodBlood, 2007
- Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1αJournal of Clinical Investigation, 2007
- Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principalsBlood, 2006
- Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set pointFree Radical Biology & Medicine, 2006
- Therapeutic stem and progenitor cell transplantation for organ vascularization and regenerationNature Medicine, 2003
- Innovative Therapies in Wound HealingJournal of Cutaneous Medicine and Surgery, 2003
- Cutaneous Wound HealingNew England Journal of Medicine, 1999
- Vascular complications in patients treated with granulocyte colony-stimulating factor (G-CSF)European Journal Of Cancer, 1993
- Colonic anastomotic healing and oxygen tensionBritish Journal of Surgery, 1985