Serologic Responses and Systemic Reactions in Adults After Vaccination with Monovalent A/USSR/77 and Trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 Influenza Vaccines
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 5 (4) , 748-757
- https://doi.org/10.1093/clinids/5.4.748
Abstract
Four hundred twenty-six volunteers aged 16 to 83 years were given experimental doses of inactivated monovalent [A/USSR/77 (H1N1)] and trivalent [A/USSR/77 (H1N1), A/Texas/77 (H3N2), B/Hong Kong/72] influenza vaccines as part of a double-blinded, placebo-controlled, national collaborative study. Local reactions at inoculation sites occurred in 1:40 in 93% of volunteers ⩾26 years of age but in only 58% of volunteers <26 years of age. In this latter group, two injections containing higher doses (10–19 µg) induced better antibody responses. Vaccines containing approximately 6–15 µg) of hemagglutinin of each antigen can be expected to be well tolerated and to induce good HAI antibody responses in a one- or two-dose regimen, depending on the age group.Keywords
This publication has 0 references indexed in Scilit: