Opiate receptor: cooperativity of binding observed in brain slices.
- 1 December 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (12) , 5764-5766
- https://doi.org/10.1073/pnas.74.12.5764
Abstract
Kinetic constants for binding of 3H-labeled morphine and naloxone were determined from Hill plot analyses and from experiments in which the concentration of tritiated drug was constant and that of nonlabeled drug varied. With [rat] brain slices, the binding of either drug exhibited strong positive cooperativity (Hill slope > 3); this was not observed in brain homogenates. In slices the relationship between opiate binding site and ligand may be more relevant physiologically and pharmacologically.This publication has 8 references indexed in Scilit:
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