Mouse Placental Transfer of F18in Comparison with Ca45

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Abstract
The placental transfer of F18 as fluoride ions has been visualized autoradiographically in mice up to one hour following intravenous injection of the isotope. The foetal skeleton is seen to accumulate much less F18 than the maternal skeleton. Following the simultaneous ingestion of F18+Ca45 an autoradiographic technique, which gives roughly similar uptake-pictures for both isotopes in the maternal skeleton, has produced uncomparably stronger Ca45-pictures of the foetal skeletons. The often occurring soptty concentrations of F18 in the fullterm mouse placenta were found to coincide with the concentrations of simultaneously injected Ca45, and to relate to the general areas of the degenerative placental calcifications. A quantitative study of the placental transfer in mice of simultaneously administered F18 and Ca45 showed a much smaller percentage of the F18 and Ca45-dose in the foetuses up to 4 hours, in spite of a more complete absorption of ingested F18. The resulted are discussed i.al. from a clinical point of view and are viewed in relation to clinical data on record in the literature.