Monoclonal C5‐1 antibody produced in transgenic alfalfa plants exhibits a N‐glycosylation that is homogenous and suitable for glyco‐engineering into human‐compatible structures
Open Access
- 10 November 2003
- journal article
- research article
- Published by Wiley in Plant Biotechnology Journal
- Vol. 1 (6) , 451-462
- https://doi.org/10.1046/j.1467-7652.2003.00041.x
Abstract
Structural analysis of the N-glycosylation of alfalfa proteins was investigated in order to evaluate the capacity of this plant to perform this biologically important post-translational modification....Keywords
This publication has 36 references indexed in Scilit:
- Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xyloseGlycobiology, 2002
- A new Chinese hamster ovary cell line expressing α2,6-sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteinsBiochimica et Biophysica Acta (BBA) - General Subjects, 2000
- INTRACELLULAR EXPRESSION IN PIG CELLS OF ANTI-??1,3GALACTOSYLTRANSFERASE SINGLE-CHAIN FV ANTIBODIES REDUCES GAL??1,3GAL EXPRESSION AND INHIBITS CYTOTOXICITY MEDIATED BY ANTI-GAL XENOANTIBODIES1Transplantation, 1998
- N‐glycans harboring the Lewis a epitope are expressed at the surface of plant cellsThe Plant Journal, 1997
- Identification of the human Lewisa carbohydrate motif in a secretory peroxidase from a plant cell suspension culture (Vaccinium myrtillus L.)FEBS Letters, 1997
- Characterization of the glycosylation of a human IgM produced by a human-mouse hybridomaGlycobiology, 1995
- Production of antibodies in transgenic plantsNature, 1989
- Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgGNature, 1985