TSH RESPONSES TO TEMPERATURE IN PRIMARY HYPOTHYROIDISM

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Abstract
The serum TSH [thyroid stimulating hormone, thyrotropin] responses to alterations in body temperature were studied by heating 12 patients with primary hypothyroidism for 48 h and determining the initial and final TSH levels. In 4 control patients, the TSH responses to rest and exercise were estimated. In 3 patients, the TSH levels were recorded at frequent intervals over 48 h, during which they were rested and subsequently warmed. In the 12 patients initially investigated, there was a significant fall in TSH. In the smaller group of 3 patients studied more intensively, TSH levels were inversely related to cutaneous and core temperature. In primary hypothyroidism alterations in body temperature apparently influence the levels of circulating TSH.

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