Picosecond radical kinetics. Rate constants for ring openings of (2-alkoxy-3-phenylcyclopropyl)methyl radicals
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 7,p. 1467-1473
- https://doi.org/10.1039/p29960001467
Abstract
Rate constants for ring openings of the (trans,trans-2-methoxy-3-phenylcyclopropyl)methyl radical (IM) and the (trans,trans-2-tert-butoxy-3-phenylcyclopropyl)methyl radical (IB) have been determined between –21 and 37 °C by indirect kinetics employing benzeneselenol trapping as the competition reaction. Radicals 1 were formed in chain reactions of the appropriate ‘PTOC esters’, 2-thioxopyridine-N-oxy derivatives of the corresponding carboxylic acids, the syntheses of which are reported. Radicals 1 rearrange with rate constants of 8 × 1011 s–1(1M) and 5 × 1011 s–1(1B) at 25 °C with predominant (160:1 and 60:1, respectively) cleavage to give benzylic radical products. The rate constants for ring openings to the minor, alkoxy-substituted radical products represent the first measurements of the kinetic effects of alkoxy substitution on cyclopropylcarbinyl radical ring openings. Precursors to radicals 1 can be employed in mechanistic probe studies that permit differentiation between radical and cationic intermediates.Keywords
This publication has 0 references indexed in Scilit: