Articulating a pharmacophore driven synthetic strategy: Discovery of a potent substance P antagonist
- 1 August 1994
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 4 (15) , 1865-1868
- https://doi.org/10.1016/s0960-894x(01)80386-3
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- Overview: Central & Peripheral Nervous System: Recent advances in the discovery and characterization of substance P antagonistsExpert Opinion on Therapeutic Patents, 1994
- Conformationally restricted analogs of CP-99,994: synthesis of a spirocyclic amineBioorganic & Medicinal Chemistry Letters, 1993
- Synthesis of (±)-CP-99994: A highly potent substance P antagonistTetrahedron Letters, 1993
- Tachykinin receptors and tachykinin receptor antagonistsJournal of Autonomic Pharmacology, 1993
- Discovery of a potent substance P antagonist: recognition of the key molecular determinantJournal of Medicinal Chemistry, 1992
- The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonistJournal of Medicinal Chemistry, 1992
- Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK 1 ) Receptor AntagonistScience, 1991
- A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) ReceptorScience, 1991
- New selective agonists for neurokinin receptors: pharmacological tools for receptor characterizationTrends in Pharmacological Sciences, 1988
- N-Trimethylsilylimines: applications to the syntheses of .beta.-lactamsJournal of the American Chemical Society, 1984