Manifestations cutanées provoquées par le lithium

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Abstract
Cutaneous side-effects are described which appeared in 5 patients under Li medication for manic-depressive disease: 2 cases with facial and dorsal acne, 1 with generalized pruritus with burning sensations on the tongue and tumefaction of the lips, 1 case with endogenous generalized psoriasis and 1 case with palmo-plantar hyperkeratosis, ichthyosis and associated with wuthyroid gioter. Li content of the tissues was assayed by flame spectrophotometry of calcinated biopsy material taken from the epidermis, dermis and subcutaneous adipose tissue from 4 of 5 cases. An experimental investigation was carried out in guinea pigs fed with Li salts during 6 mo. The cation was assayed in samples of epidermis, dermis and perirenal adipose tissue. A study of Li accumulation in epidermal, dermal and adipose tissue was made.

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