Nicotine Inhibition of the Metabolism of 3,4-Benzopyrene, a Carcinogen in Tobacco Smoke
- 7 June 1974
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4141) , 1081-1083
- https://doi.org/10.1126/science.184.4141.1081
Abstract
A decreased rate of biliary excretion of radioactive metabolites of 3,4-benzopyrene was observed in rats given a single dose of nicotine. Prior treatment of rats with nicotine decreased benzopyrene hydroxylase activity in homogenates of liver, lung, and small intestine. The addition of nicotine to incubated tissues also decreased benzopyrene hydroxylase activity. These findings show that nicotine inhibits the metabolism of 3,4-benzopyrene in vivo and in vitro.Keywords
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