The influence of intravenous magnesium sulphate on the occurrence of atrial fibrillation after coronary artery by-pass operation
- 1 February 1993
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 14 (2) , 251-258
- https://doi.org/10.1093/eurheartj/14.2.251
Abstract
To examine the influence of (Mg) on hypomagnesaemia and atrial fibrillation (AF) following coronary artery by-pass surgery, 140 consecutive patients were randomized to receive 70 mmol of magnesium sulphate intravenously (n = 69) or placebo (n = 71). Serum magnesium concentrations fell to 0.77 ± 0.10 mmol. l−1 in the control group but rose to 1.09 ± 0.17 mmol. l−1 in the Mg group (P −1; P l−1; P P = 0.056). In patients experiencing AF during the first three post-operative days, serum Mg concentrations were higher and SR slower on each day compared with non-AF patients. SR increased post-operatively less with high Mg levels (P = 0.044). In the Mg group, serum Mg and SR were the only independent predictors of AF. In conclusion, the incidence of post-operative AF is not decreased with magnesium. High Mg levels are likely to provoke AF probably by mechanisms that modify SR.Keywords
This publication has 0 references indexed in Scilit: