DRUG EFFECT ON BLINK RATES IN RHESUS-MONKEYS - PRELIMINARY STUDIES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 16  (3) , 249-254
Abstract
Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean .+-. SD blink rate slightly to 18.2 .+-. 5.3 blinks/90 s. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 .+-. 7.6 blinks/90 s to 37 .+-. 15 blinks/90 s. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 .+-. 2.8 blinks/90 s to 41.9 .+-. 10.3 blinks/90 s and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

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