One-pot Synthesis of Substituted Quinolines by Iridium-catalyzed Three-component Coupling Reaction
- 1 January 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 34 (1) , 106-107
- https://doi.org/10.1246/cl.2005.106
Abstract
A convenient and efficient synthesis of substituted quinolines in a simple one-pot reaction of an arylamine 1, an aromatic aldehyde or aliphatic aldehyde 2 and an aliphatic aldehyde 3 in the presence of transition metal complexes or Lewis acids was developed. Among them, the iridium catalyst [Ir(cod)Cl]2 catalyzed the reaction most efficiently.Keywords
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