THE DEVELOPMENT OF AN ACQUIRED HAEMOGLOBIN ABNORMALITY CAUSED BY THERMAL INJURY

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Abstract
Alkali denaturation of the hemoglobin derived from burned patients at various intervals from the time of the injury was investigated. A delayed denaturation curve was always found. The involvement of the transfused cells was established by a differential agglutination technique. Red cell populations were fractionated into two portions, one of which was probably enriched in younger cells. This portion was preferentially affected. A starch gel technique yielded a "slow" and a "fast" fraction of hemoglobin with differing denaturation rates, even in normals. The "slow" fraction appeared to be increased quantitatively and qualitatively, if compared with normal blood.