THE EFFECT OF HUMAN PLASMA ON THE ANTICOAGULANT ACTIVITY OF HEPARIN 1

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Abstract
Plasma from normal human subjects and from patients with certain thrombotic and hemorrhagic diseases was incubated with heparin for 4 hrs. at 37[degree]C. No evidence was obtained that the anticoagulant activity of heparin was altered by any of the plasma tested. Acidified plasma did not reduce heparin activity, suggesting that the "heparinase" of Jaques is not present in plasma. The concn. of heparin required to inhibit coagulation of virtually platelet-free plasma was related to the glass surface area to which the plasma was exposed.
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