Apolipoprotein E genotypes and age of onset in early‐onset familial Alzheimer's disease
- 8 October 1995
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 38 (4) , 678-680
- https://doi.org/10.1002/ana.410380420
Abstract
The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage to chromosome 14. The ϵ4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early‐onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE‐independent pathways.Keywords
This publication has 16 references indexed in Scilit:
- The apolipoprotein E ε4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutationsAnnals of Neurology, 1994
- Alzheimer's Disease and Possible Gene InteractionScience, 1994
- Apolipoprotein E polymorphism and Alzheimer's diseaseThe Lancet, 1993
- Apolipoprotein E genotype and Alzheimer's diseaseThe Lancet, 1993
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14Science, 1992
- Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein geneNature, 1991
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- Familial alzheimer's disease in american descendants of the volga germans: Probable genetic founder effectAnnals of Neurology, 1988
- Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European familiesNature, 1987