Splenic lipofuscinosis in mice
- 1 October 1978
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 126 (2) , 113-120
- https://doi.org/10.1002/path.1711260210
Abstract
Autopsy examination of young adult mice revealed a characteristic pigmentation of the anterior splenic pole occurring in a high proportion (8-34%) of 3 mouse strains and 2 sublines. Histological studies identified the pigment as lipofuscin and EM provided supporting evidence. Lipofuscin may represent non-metabolizable debris from cellular breakdown associated with lysosomal activity.Keywords
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