Specific Soluble Antigen in the Blood of Filarial Patients

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Abstract
Using two antigens, one prepared from the adult worm and the other from the larvae of Dirofilaria immitis, the presence of 2 antibodies in the sera of filarial patients was demonstrated. The presence of circulating soluble antigen was detected also in the sera of a large number of persons who had a microfilaremia. Preliminary expts. indicate that sera containing this antigen (or antigens) might be utilized for diagnostic tests in filariasis. In one expt., the results suggest that this antigen (or antigens) appears in the blood as a tide whose ebb and flow are related inversely to the different concentrations of the microfilariae in the circulation.

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