The effects of cholecystokinin octapeptide on human isolated alimentary muscle

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Abstract
We studied cholecystokinin octapeptide (CCK‐OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. CCK‐OP induced a concentration‐dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. CCK‐OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones.

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