Chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog

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Abstract
Six dogs were given chenodeoxycholic acid, 200 mg/day orally for 15 days; gallbladder and hepatic bile samples were taken and biliary bile acids, phospholipids and cholesterol were compared to those of 14 control dogs. Cholesterol saturation index of gallbladder bile was higher in treated dogs (0.12 .+-. 0.06; m .+-. SD) than in controls (0.07 .+-. 0.01; P < 0.05); the proportion of chenodeoxycholic acid in gallbladder bile was higher in treated dogs (27.8 .+-. 12.5%) than in controls (4.5 .+-. 1.9%; P < 0.01); in hepatic bile, the saturation index and proportion of chenodeoxycholic acid were significantly higher in treated dogs (0.13 .+-. 0.03 and 21.6 .+-. 8.8%, respectively) than in control dogs (0.07 .+-. 0.01; P < 0.01 and 4.6 .+-. 2.2%; P < 0.01, respectively). In the dog, chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile. The difference of effect of chenodeoxycholic acid in man and in the dog is not related to the duration of administration, but to a species difference.