A series of 60 cases of Cat Scratch Disease from widespread areas in this country is reported. The entity classically consists of regional lymphadenitis with or without the formation of sterile pus following cat scratch and an initial lesion on the skin. The initial lesion may assume a variety of forms and is present in almost half of the cases. Suppuration with sterile pus occurred in about 1/3 of the patients. Rarely there is no history of cat contact. The disease may simulate any of wide variety of neoplastic or inflammatory diseases involving regional lymph nodes. The axillary nodes are the most frequent of the regional nodes to be involved but a cervical form is common. The majority of the patients have a short, mild illness with fever and systemic symptoms, but indolent or suppurative node involvement may persist for months. There is a specific intradermal test. The nodes have a characteristic though not diagnostic microscopic pattern. Present evidence suggests that the disease may be due to a virus related to the lymphogranuloma-psittacosis groups.