Glycyrrhetinic Acid—A Triterpene with Anti-Oestrogenic and Anti-Inflammatory Activity

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Abstract
Glycyrrhetinic acid was found to resemble the Δ4-3-ketosteroids in antagonising uterine growth response to exogenous oestrogen in doses which did not interfere with somatic growth or the oestrogenic effect on pituitary trophic hormones. The anti-oestrogenic effect was not mediated through gonadal inhibition, adrenal stimulation or potentiation of endogenous adrenal corticoids. Glycyrrhetinic acid is neither androgenic, oestrogenic nor anti-androgenic. However, it does resemble the glucocorticoids in depressing granuloma tissue formation in adrenalectomised rats.