Treatment of Hypercholesterolemia with Neomycin — A Time for Reappraisal
- 13 September 1979
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 301 (11) , 595-597
- https://doi.org/10.1056/nejm197909133011108
Abstract
IN 1958 a serendipitous observation led to the discovery that oral administration of small doses of neomycin reduced the concentration of plasma cholesterol in man.1 Neomycin is a nonabsorbable aminoglycoside antibiotic with a broad spectrum of activity. Since intramuscular administration of small absorbed amounts (2 My colleagues and I have studied the effects of 22 additional antibacterial drugs on plasma cholesterol levels in man; kanamycin, chlortetracycline, paromomycin, chloramphenicol and para-aminosalicylic acid . . .Keywords
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