Diazoxide-induced Diabetes Mellitus in a Hypopituitary Dwarf

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Abstract
The suc-cessful application of the well-documented hyperglycemic effect of diazoxide to the management of hypoglycemic states has been previously reported. The present report describes the response of a hypopituitary dwarf to diazoxide administration. Diabetes mellitus, complicated by ketosis, was rapidly induced. Discontinuation of diazoxide therapy was followed by clearing of diabetes over the next 5 days. A comparison of the diazoxide response of this child to that of a child with leucine sensitivity is made. The possible mechanisms by which diazoxide induces hyperglycemia are discussed.