Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus
- 31 March 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 147 (3) , 315-316
- https://doi.org/10.1007/bf00442705
Abstract
Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%–40%), the mean fall was 24% (P<0.005). Though none of the infants showed signs of impaired cerebral function during or following the injections, the results do not indicate whether or not the use of indomethacin is a potential hazard.Keywords
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