Deposition of Monodisperse Insoluble Aerosol Particles in the 0.005 to 0.2 μm Size Range Within the Human Respiratory Tract
- 1 January 1988
- journal article
- Published by Oxford University Press (OUP) in Annals of Work Exposures and Health
Abstract
In 4 subjects with normal lung function total deposition of monodisperse, hydrophobic, uncharged silver particles in the 0.005 to 0.08 μm size range was investigated for a variety of breathing patterns during steady state mouth- and nose breathing. The evaluation of deposition was based upon measurements of mean particle number concentration in inspired and expired air by means of a condensation nucleus counter. Owing to the diffusional particle transport, total deposition increases with decreasing particle size and increasing mean residence time of the aerosol in the lungs. With decreasing particle size the time dependence becomes less and the effect of tidal volume more significant. A semi-empirical formula is derived which fits the experimental data.Keywords
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