EFFECT OF HALOTHANE ANAESTHESIA ON DISTRIBUTION OF CARDIAC OUTPUT AND ORGAN BLOOD FLOW IN THE RABBIT

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Abstract
Organ blood flow was measured in rabbits during halothane anaesthesia by the injection of a bolus of radioactive labelled microspheres into the left ventricle. The results were compared with those found in unanaesthetized rabbits. Halothane caused a fall in total blood flow with no change in peripheral resistance. Blood flow to most organs was reduced to the same extent as was cardiac output. There was no evident pronounced redistribution of blood as is seen in low output states from other causes. Halothane appears to exert its main cardiovascular effects by myocardial depression together with an inhibition of vascular reflexes.

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