APLASTIC-ANEMIA - FAILURE OF PATIENT LEUKOCYTES TO STIMULATE ALLOGENEIC CELLS IN MIXED LEUKOCYTE-CULTURE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 47  (5) , 793-799
Abstract
One-way mixed leukocyte cultures were used to study the ability of cells from 53 patients with aplastic anemia and 65 of their HL-A-identical siblings to stimulate and to respond to cells from unrelated individuals. The capacity of leukocytes from 28 of 53 patients to stimulate was diminished or absent; their ability to respond remained comparable to that of cells from their HL-A-identical siblings. Leukocytes from the group of patients with the lowest peripheral lymphocyte count were least stimulatory. In acquired aplastic anemia, there is a dissociation between stimulation and response in mixed culture.

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