RENAL TISSUE OXYGENATION FOLLOWING INDUCED HYPOTENSION IN DOGS
Open Access
- 1 September 1984
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 56 (9) , 1037-1043
- https://doi.org/10.1093/bja/56.9.1037
Abstract
Renal oxygenation was studied during indnrrd hypotension in mongrel dogs, anaesthetized with 1–1.5% halothane in oxygen. Hypotension was induced with an infusion i.v. of sodium nitroprusside (SNP) 70±l7 μg kg-1−1min−1 (mean±SEM) or trimetaphan (TMP) 36±16 μg kg−1min−1, or by controlled arterial haemorrhage (45±6 ml/kg of body weight). Mean arterial pressure (MAP), cortical (Pct2) and medullary (PmtO2) tissue oxygen tensions, arterial (PaO2), renal venous (PrvO2), and urine PuO2) oxygen tensions were measured during the 40-min control, hypotension, and recovery periods. MAP was decreased to approximately 60% of the control value, PctO2 decreased significantly (PPmtO2 decreased significantly only in the haemorrhage group. Upon restoration of MAP to normal values, renal tissue oxygen tensions recovered in all groups, somewhat more rapidly in the SNP group. There were no significant differences in PaO2, PrvO2 and PuO2 during control, hypotension and recovery periods in the three groups. Tissue oxygen tension values followed the changes in MAP; but were not hypoxic, leading us to believe that both SNP and TMP are hypotensive agents safe for the kidneyThis publication has 0 references indexed in Scilit: