Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma
- 2 May 2006
- journal article
- Published by Springer Nature in Prostate Cancer and Prostatic Diseases
- Vol. 9 (4) , 414-419
- https://doi.org/10.1038/sj.pcan.4500874
Abstract
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoural tissue and benign prostate hyperplasia (PPP<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.Keywords
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