Chromosomal locations of the gene coding for the CD3 (T3) ? subunit of the human and mouse CD3/T-cell antigen receptor complexes

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Abstract
The gene coding for the M r 26000 γ chain of the human CD3 (T3) antigen/T-cell antigen receptor complex was mapped to chromosome band 11q23 by using a cDNA clone (pJ6T3 γ-2), by in situ hybridization to metaphase chromosomes and by Southern blot analysis of a panel of human-rodent somatic cell hybrids. The mouse homolog, here termed Cdg-3, was mapped to chromosome 9 using the mouse γ cDNA clone pB10.AT3 γ-1 and a panel of mouse-hamster somatic cell hybrids. Similar locations for the CD3 δ genes have been described previously. Thus, the corporate results indicate that the CD3 γ and δ genes have remained together since they duplicated about 200 million years ago.