CORTICOLIBERIN (CRF) ACTIVITY OF RAT NEUROHYPOPHYSIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 12  (4) , 204-208
Abstract
Corticoliberin (CRF) activity of the rat stalk-median eminence region (SME) and neural lobe of the pituitary (NL) was tested in vitro using cultured cells of anterior pituitary. The activity of NL was more than 50% lower than that of SME. The parallelism of dose-response curves suggests that ACTH/releasing substances originating from NL and SME may be qualitatively identical. Neurosecretory cells producing corticoliberin apparently form a continuous neurohemal system of the median eminence, the stalk and the neural lobe.